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Creators/Authors contains:
"Peck, Hannah E"
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Radmand, Afsane; Kim, Hyejin; Beyersdorf, Jared; Dobrowolski, Curtis N.; Zenhausern, Ryan; Paunovska, Kalina; Huayamares, Sebastian G.; Hua, Xuanwen; Han, Keyi; Loughrey, David; et al (, Proceedings of the National Academy of Sciences)Adding a cationic helper lipid to a lipid nanoparticle (LNP) can increase lung delivery and decrease liver delivery. However, it remains unclear whether charge-dependent tropism is universal or, alternatively, whether it depends on the component that is charged. Here, we report evidence that cationic cholesterol-dependent tropism can differ from cationic helper lipid-dependent tropism. By testing how 196 LNPs delivered mRNA to 22 cell types, we found that charged cholesterols led to a different lung:liver delivery ratio than charged helper lipids. We also found that combining cationic cholesterol with a cationic helper lipid led to mRNA delivery in the heart as well as several lung cell types, including stem cell-like populations. These data highlight the utility of exploring charge-dependent LNP tropism.more » « less
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Rotolo, Laura; Vanover, Daryll; Bruno, Nicholas C.; Peck, Hannah E.; Zurla, Chiara; Murray, Jackelyn; Noel, Richard K.; O’Farrell, Laura; Araínga, Mariluz; Orr-Burks, Nichole; et al (, Nature Materials)
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Beyersdorf, Jared P.; Bawage, Swapnil; Iglesias, Nahid; Peck, Hannah E.; Hobbs, Ryan A.; Wroe, Jay A.; Zurla, Chiara; Gersbach, Charles A.; Santangelo, Philip J. (, ACS Nano)
